Pokémon is no exception to this rule as one of the most famous video game challenges of all time is the Nuzlocke Run which actually makes the Pokémon games exceedingly difficult. There are a whole variety of them ranging from a no-kill run in Metal Gear Solid to only using your knife as a weapon in Resident Evil 4. Self-made video game challenges and runs have been a staple in recent gaming and can create exciting and new ways to replay your favorite games. Update: This article will soon include analysis from Pokemon Scarlet and Violet which an article dedicated to it is currently out.